Cardano founder Charles Hoskinson predicts that Bitcoin DeFi could surpass Ethereum and Solana within 24–36 months, citing Bitcoin’s unmatched liquidity and scale. He envisions Bitcoin evolving from a “sleeping giant” into the dominant DeFi platform, leveraging bridges like Grail Bridge and projects such as BitcoinOS to connect Bitcoin liquidity with Cardano’s ecosystem. Hoskinson also plans educational initiatives to accelerate developer adoption. However, challenges remain, including Bitcoin’s limited smart contract functionality, reliance on secure bridges, and competition from established DeFi ecosystems. Success depends on overcoming interoperability risks, scaling hurdles, and achieving broad user and developer adoption worldwide.